WHITE OPAQUE SUBSTANCE, A NEW OPTICAL MARKER ON MAGNIFYING ENDOSCOPY: USEFULNESS IN DIAGNOSING COLORECTAL EPITHELIAL NEOPLASMS

White Opaque Substance, a New Optical Marker on Magnifying Endoscopy: Usefulness in Diagnosing Colorectal Epithelial Neoplasms

Background/Aims Vacuum Flasks A white substance that is opaque to endoscopic light is sometimes observed in the epithelium during narrowband imaging with magnifying endoscopy of gastric or colorectal epithelial neoplasms.This prospective observational study aimed to determine whether the morphology of the white opaque substance (WOS) allows differe

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Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons

Axons are equipped with the digital signaling capacity by which they generate and faithfully propagate action potentials (APs), and also with the analogue signaling capacity Wall Clocks by which subthreshold activity in dendrites and soma is transmitted down the axon.Despite intense work, the extent and physiological role for subthreshold synaptic

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pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model.

Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing.Therefore, despite suboptimal clinical effects, gemcitabine (GEM) remains the first-line chemotherapeutic drug in the clinic for PDAC treatment.The therapeutic limitations of GEM are primaril

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